“The capability to quantify the Covid-19 antibody concentration will be crucial in estimating the declining antibody response over time and hence its possible impact on immunity against recurrence of infection. IISc added that PathShodh’s technique, which is protected through US and Indian patent applications, is a major departure from the qualitative rapid antibody tests in the market, which are primarily based on the lateral flow ELISA technique. It can work with venous or capillary (finger-prick) whole blood samples as well as serum samples.” Vinay Kumar, CEO and co-founder of PathShodh said that “This novel technology can detect Covid-19 antibodies all the way down to the nanomolar concentration. Hence, those antibody tests which target the S1 spike protein are more representative of an immune response against infection compared to those that target the Nucleocapsid (N) protein. The S1 protein has a Receptor Binding Domain (RBD) which latches on to the host cell’s ACE2 receptors before infection. Invented by PathShodh Healthcare, a start-up incubated at the Society for Innovation and Development (SID) at the Indian Institute of Science (IISc), the test can measure the electrochemical redox activity of IgM and IgG antibodies specific to the Sars-CoV-2 Spike Glycoprotein (S1). The test can determine levels of Covid-prompted IgM and IgG antibodies. VelocityException: Failed to initialize an instance of .log.Log4JLogChute with the current runtime configuration.Īt .(LogManager.java:206)Īt .(LogManager.java:255)Īt .RuntimeInstance.initializeLog(RuntimeInstance.java:795)Īt .RuntimeInstance.init(RuntimeInstance.java:250)Īt .RuntimeInstance.init(RuntimeInstance.java:589)Īt .RuntimeSingleton.init(RuntimeSingleton.java:229)Īt .Velocity.init(Velocity.java:107)Īt .Velocit圜onfigurator.initVelocity(Velocit圜onfigurator.java:57)Īt .Velocit圜nfigure(Velocit圜onfigurator.java:42)Īt .contextInitialized(VelociListener.java:26)Īt .StandardContext.listenerStart(StandardContext.java:3827)Īt .StandardContext.start(StandardContext.java:4336)Īt .ContainerBase.addChildInternal(ContainerBase.java:761)Īt .ContainerBase.addChild(ContainerBase.java:741)Īt .StandardHost.addChild(StandardHost.java:525)Īt .ployDescriptor(HostConfig.java:626)Īt .ployDescriptors(HostConfig.java:553)Īt .ployApps(HostConfig.java:488)Īt .HostConfig.start(HostConfig.java:1138)Īt .HostConfig.lifecycleEvent(HostConfig.java:311)Īt .LifecycleSupport.fireLifecycleEvent(LifecycleSupport.java:120)Īt .ContainerBase.start(ContainerBase.java:1023)Īt .StandardHost.start(StandardHost.java:719)Īt .ContainerBase.start(ContainerBase.java:1015)Īt .StandardEngine.start(StandardEngine.java:443)Īt .StandardService.start(StandardService.java:448)Īt .StandardServer.start(StandardServer.java:710)Īt .Catalina.start(Catalina.java:552)Īt 0(Native Method)Īt (NativeMethodAccessorImpl.java:39)Īt (DelegatingMethodAccessorImpl.java:25)Īt .invoke(Method.java:597)Īt .Bootstrap.start(Bootstrap.java:288)Īt .Bootstrap.main(Bootstrap.java:413)Ĭaused by: : Error configuring Log4JLogChute :Īt 0(Native Method)Īt (NativeConstructorAccessorImpl.java:39)Īt (DelegatingConstructorAccessorImpl.java:27)Īt .newInstance(Constructor.java:513)Īt .ExceptionUtils.createWithCause(ExceptionUtils.java:67)Īt .ExceptionUtils.createRuntimeException(ExceptionUtils.java:45)Īt .(Log4JLogChute.java:133)Īt .(Log4JLogChute.java:85)Īt .(LogManager.java:157)Ĭaused by: java.io.FileNotFoundException: velocity.log (Permission denied)Īt java.io.FileOutputStream.openAppend(Native Method)Īt java.io.FileOutputStream.(FileOutputStream.java:177)Īt java.io.FileOutputStream.(FileOutputStream.java:102)Īt .setFile(FileAppender.java:290)Īt .setFile(RollingFileAppender.java:194)Īt .(FileAppender.java:109)Īt .(RollingFileAppender.java:72)Īt .(Log4JLogChute.java:118)ĮRROR (Velocit圜onfigurator.java:63) - : Error configuring Log4JLogChute :ĮRROR (Velocit圜onfigurator.java:64) - Failed to initialize an instance of .log.Log4JLogChute with the current runtime configuration.Īt .Velocit圜nfigure(Velocit圜onfigurator.Researchers at the Indian Institute of Science (IISc) have made a breakthrough development of a semi-quantitative electrochemical ELISA test for Covid-19. But when I tried to deploy, velocity crashes in init(), leaving me with this strange stack trace here (sorry for the size):ĮRROR (Velocit圜onfigurator.java:62) - Error initializing Velocity! I built a webapp that works perfectly fine in my localhost (tomcat).
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